Medical University of Vienna, Austria

Medical University of Vienna
Department of Dermatology
Währinger Gürtel 18-20, 1090 Wien
T: +43 (0)1 40400-0
M3 Study Group
Department of Dermatology
Medical University of Vienna
Währinger Gürtel 18-20
A-1090 Vienna, Austria

Group leader

Ichiro Okamoto
ichiro.okamoto@meduniwien.ac.at
Tel: +43-(0)1-40400-77000

Group members

Judith Wendt
judith.wendt@meduniwien.ac.at
Tel: +43-(0)1-40400-77000

Christoph Müller
christoph.mueller@meduniwien.ac.at
Tel: +43-(0)1-40400-77000

Research area

The M3-study (Molecular Marker in Melanoma) has been established in 2008 to study genetic and phenotypic markers of melanoma risk and progression of current patients. Patients’ recruitment including controls for studies identifying risk factors are ongoing. So far, more than 1800 melanoma patients and more than 1600 controls have participated to this study. Participants with familial melanoma background, multiple primary melanomas and young melanoma patients are of special interest. The following list represents the most recent scientific output by the group:

List of publications

  • Wendt J., Rauscher S., Burgstaller-Muehlbacher S., Fae I., Fischer G., Pehamberger H., Okamoto I. (2016) Human Determinants and the Role of Melanocortin-1-Receptor Variants in Melanoma Risk Independent of UV Radiation Exposure, JAMA Dermatology
  • Davies, J. R., Jewell, R., Affleck, P., Anic, G. M., Randerson-Moor, J., Ozola, A., Egan, K. M., Elliott, F., Garcia-Casado, Z., Hansson, J., Harland, M., Hoiom, V., Jian, G., Jonsson, G., Kumar, R., Nagore, E., Wendt, J., Olsson, H., Park, J. Y., Patel, P., Pjanova, D., Puig, S., Schadendorf, D., Sivaramakrishna Rachakonda, P., Snowden, H., Stratigos, A. J., Bafaloukos, D., Ogbah, Z., Sucker, A., Van den Oord, J. J., Van Doorn, R., Walker, C., Okamoto, I., Wolter, P., Barrett, J. H., Timothy Bishop, D. & Newton-Bishop, J. (2014) Inherited variation in the PARP1 gene and survival from melanoma, Int J Cancer. 135, 1625-33. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/24535833 International Journal of Cancer: http://onlinelibrary.wiley.com/doi/10.1002/ijc.28796/abstract http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106984/
  • Davies, J. R., Field, S., Randerson-Moor, J., Harland, M., Kumar, R., Anic, G. M., Nagore, E., Hansson, J., Hoiom, V., Jonsson, G., Gruis, N. A., Park, J. Y., Guan, J., Sivaramakrishna Rachakonda, P., Wendt, J., Pjanova, D., Puig, S., Schadendorf, D., Okamoto, I., Olsson, H., Affleck, P., Garcia-Casado, Z., Puig-Butille, J. A., Stratigos, A. J., Kodela, E., Donina, S., Sucker, A., Hosen, I., Egan, K. M., Barrett, J. H., van Doorn, R., Bishop, D. T. & Newton-Bishop, J. (2014) An inherited variant in the gene coding for vitamin D-binding protein and survival from cutaneous melanoma: a BioGenoMEL study, Pigment Cell Melanoma Res. 27, 234-43. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/24219834 Pigment Cell & Melanoma Research: http://onlinelibrary.wiley.com/doi/10.1111/pcmr.12193/abstract http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065372/
  • Iles, M. M., Law, M. H., Stacey, S. N., Han, J., Fang, S., Pfeiffer, R., Harland, M., Macgregor, S., Taylor, J. C., Aben, K. K., Akslen, L. A., Avril, M. F., Azizi, E., Bakker, B., Benediktsdottir, K. R., Bergman, W., Scarra, G. B., Brown, K. M., Calista, D., Chaudru, V., Fargnoli, M. C., Cust, A. E., Demenais, F., de Waal, A. C., Debniak, T., Elder, D. E., Friedman, E., Galan, P., Ghiorzo, P., Gillanders, E. M., Goldstein, A. M., Gruis, N. A., Hansson, J., Helsing, P., Hocevar, M., Hoiom, V., Hopper, J. L., Ingvar, C., Janssen, M., Jenkins, M. A., Kanetsky, P. A., Kiemeney, L. A., Lang, J., Lathrop, G. M., Leachman, S., Lee, J. E., Lubinski, J., Mackie, R. M., Mann, G. J., Martin, N. G., Mayordomo, J. I., Molven, A., Mulder, S., Nagore, E., Novakovic, S., Okamoto, I., Olafsson, J. H., Olsson, H., Pehamberger, H., Peris, K., Grasa, M. P., Planelles, D., Puig, S., Puig-Butille, J. A., Randerson-Moor, J., Requena, C., Rivoltini, L., Rodolfo, M., Santinami, M., Sigurgeirsson, B., Snowden, H., Song, F., Sulem, P., Thorisdottir, K., Tuominen, R., Van Belle, P., van der Stoep, N., van Rossum, M. M., Wei, Q., Wendt, J., Zelenika, D., Zhang, M., Landi, M. T., Thorleifsson, G., Bishop, D. T., Amos, C. I., Hayward, N. K., Stefansson, K., Bishop, J. A. & Barrett, J. H. (2013) A variant in FTO shows association with melanoma risk not due to BMI, Nat Genet. 45, 428-32. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23455637 Nature genetics: http://www.nature.com/ng/journal/v45/n4/full/ng.2571.html http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640814/
  • Davies, J. R., Field, S., Randerson-Moor, J., Harland, M., Kumar, R., Anic, G. M., Nagore, E., Hansson, J., Hoiom, V., Jonsson, G., Gruis, N. A., Park, J. Y., Jian, G., Rachakonda, P. S., Wendt, J., Pjanova, D., Puig, S., Schadendorf, D., Okamoto, I., Olsson, H., Affleck, P., Garcia-Casado, Z., Puig-Butille, J. A., Stratigos, A. J., Kodela, E., Donina, S., Sucker, A., Hosen, I., Egan, K. M., Barrett, J. H., van Doorn, R., Bishop, D. T. & Newton-Bishop, J. (2013) An inherited variant in the gene coding for vitamin D binding protein and survival from cutaneous melanoma: a BioGenoMEL study, Pigment Cell Melanoma Res. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/24219834 Pigment Cell & Melanoma Research: http://onlinelibrary.wiley.com/doi/10.1111/pcmr.12193/abstract http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065372/
  • Stacey, S. N., Sulem, P., Masson, G., Gudjonsson, S. A., Thorleifsson, G., Jakobsdottir, M., Sigurdsson, A., Gudbjartsson, D. F., Sigurgeirsson, B., Benediktsdottir, K. R., Thorisdottir, K., Ragnarsson, R., Scherer, D., Hemminki, K., Rudnai, P., Gurzau, E., Koppova, K., Botella-Estrada, R., Soriano, V., Juberias, P., Saez, B., Gilaberte, Y., Fuentelsaz, V., Corredera, C., Grasa, M., Hoiom, V., Lindblom, A., Bonenkamp, J. J., van Rossum, M. M., Aben, K. K., de Vries, E., Santinami, M., Di Mauro, M. G., Maurichi, A., Wendt, J., Hochleitner, P., Pehamberger, H., Gudmundsson, J., Magnusdottir, D. N., Gretarsdottir, S., Holm, H., Steinthorsdottir, V., Frigge, M. L., Blondal, T., Saemundsdottir, J., Bjarnason, H., Kristjansson, K., Bjornsdottir, G., Okamoto, I., Rivoltini, L., Rodolfo, M., Kiemeney, L. A., Hansson, J., Nagore, E., Mayordomo, J. I., Kumar, R., Karagas, M. R., Nelson, H. H., Gulcher, J. R., Rafnar, T., Thorsteinsdottir, U., Olafsson, J. H., Kong, A. & Stefansson, K. (2009) New common variants affecting susceptibility to basal cell carcinoma, Nat Genet. 41, 909-14. Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19578363 Nature genetics: http://www.nature.com/ng/journal/v41/n8/full/ng.412.html http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973331/