NE Italy Melanoma Families Group

Our institution

National Cancer Institute

Our group

North Eastern Italy Melanoma Families Group
Genetic Epidemiology Branch
Division of Cancer Epidemiology and Genetics
National Cancer Institute
NIH/DHHS
Executive Plaza South
6120 Executive Blvd., Room 7114
Bethesda, MD 20892-7236
USA

The Group leader

Maria Teresa Landi, M.D., Ph.D.
Genetic Epidemiology Branch
Division of Cancer Epidemiology and Genetics
National Cancer Institute
NIH/DHHS
Executive Plaza South
6120 Executive Blvd., Room 7114
Bethesda, MD 20892-7236
USA

Tele: 01-301-402-9519
Fax: 01-301-402-4489
Email: landim@mail.nih.gov

We initiated a genetic epidemiologic study of familial melanoma in Cesena, Italy in 1994, in the North Eastern area of Italy. The major goal of the study is to investigate the genetic and environmental determinants of melanoma, in families with 2 or more relatives with melanoma. Multiple primary melanoma, dysplastic nevi, and pancreatic cancer cases are present in several families.

For families with no mutations in the CDKN2A gene, we search for additional susceptibility loci for melanoma. In addition, we study the contribution of modifier genes, including those involved in pigmentation, immune regulation, and DNA repair, and their interaction with environmental factors in the genesis of melanoma. Patients are evaluated at the Maurizio Bufalini Hospital of Cesena, Italy. The team currently include genetic epidemiologists, physicians, technicians, and laboratory investigators.

Related Links

National Cancer Institute
http://cancer.gov/

Genetic Epidemiology Branch
http://dceg.cancer.gov/genetic.html

The names and e-mail addresses of group members with a description of their contribution

Principal researchers

Maria Teresa Landi, MD, PhD
landim@mail.nih.gov

Alisa Goldstein, PhD
goldstea@mail.nih.gov

Margaret Tucker, MD
tuckerp@mail.nih.gov

Donato Calista
calista@iol.it

Labratory Scientists

Shirley Tsang, PhD
st248s@nih.gov

David Munroe, PhD
dm368n@nih.gov